A new study shows that NR (nicotinamide riboside) which is a precursor of NAD+, which can be ingested as a supplement has stopped and reversed the aging of muscles in aging mice. Researchers wanted to reactivate the stem cells in the muscle by targeting molecules that help the mitochondria function properly. Mitochondria is the power generator of the cell and slowing down its function is usually associated with aging/degeneration processes. The stem cells are able to regenerate/repair tissue and organs by producing new, healthy cells. It is believed that the NR effect of helping the mitochondria work better and therefore help the stem cells kick back into action is not limited to the muscle tissue but it can help any other tissue/organs. It also might be able to help with tissue repair following injury or with degenerative processes that affect even young people.
So far, there is no negative effect associated with the administration of NR, even at high doses but further studies are warranted.
Hongbo Zhang, Dongryeol Ryu, Yibo Wu, Karim Gariani, Xu Wang, Peiling Luan, Davide D’amico, Eduardo R. Ropelle, Matthias P. Lutolf, Ruedi Aebersold, Kristina Schoonjans, Keir J. Menzies, Johan Auwerx. NAD repletion improves mitochondrial and stem cell function and enhances lifespan in mice. Science, 2016 DOI: 10.1126/science.aaf2693